TGFβ Type II Receptor Signaling Controls Schwann Cell Death and Proliferation in Developing Nerves

Abstract excerpt

During development, Schwann cell numbers are precisely adjusted to match the number of axons. It is essentially unknown which growth factors or receptors carry out this important control in vivo. Here, we tested whether the type II transforming growth factor (TGF) beta receptor has a role in this process. We generated a conditional knock-out mouse in which the type II TGFbeta receptor is specifically ablated only...

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