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Article

Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in mice.

Cancer science - 1 May 2005

Lee Gang-Hong, Matsushita Hiroshi

Abstract excerpt

Pol iota is a member of the Y-family DNA polymerases, characterized by their capacity for translesion DNA synthesis and low fidelity base incorporation, and has therefore been assumed to play important roles in mutagenesis and carcinogenesis. In fact, the mouse Pol iota gene is located within the Par2 (pulmonary adenoma resistance 2) locus on distal chromosome 18, which we have identified as a major...

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Identifiers

PMID: 15904465
DOI: 10.1111/j.1349-7006.2005.00042.x
PMCID: PMC11158430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in mice.PMID 15904465Read ↗

Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia.Semantic proximity Read ↗

Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2.Semantic proximity Read ↗

The error-prone DNA polymerase ι provides quantitative resistance to lung tumorigenesis and mutagenesis in mice.Semantic proximity Read ↗

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Identification of the Par2 (Pulmonary adenoma resistance) locus on mouse chromosome 18, a major genetic determinant for lung carcinogen resistance in BALB/cByJ mice.Semantic proximity Read ↗

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