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Article

UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota.

Molecular and cellular biology - 1 Oct 2006

Ohkumo Tsuyoshi, Kondo Yuji, Yokoi Masayuki, Tsukamoto Tetsuya, Yamada Ayumi, Sugimoto Taiki, Kanao Rie, Higashi Yujiro, Kondoh Hisato, Tatematsu Masae, Masutani Chikahide, Hanaoka Fumio

Abstract excerpt

DNA polymerase eta (Pol eta) is the product of the Polh gene, which is responsible for the group variant of xeroderma pigmentosum, a rare inherited recessive disease which is characterized by susceptibility to sunlight-induced skin cancer. We recently reported in a study of Polh mutant mice that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17015482
DOI: 10.1128/MCB.01076-06
PMCID: PMC1636855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17015482-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota.PMID 17015482Read ↗

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Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations.Semantic proximity Read ↗

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