Article
The Elp3 subunit of human Elongator complex is functionally similar to its counterpart in yeast.
Molecular genetics and genomics : MGG - 1 May 2005
Li Fen, Lu Jun, Han Qiuju, Zhang Guoping, Huang Baiqu
Abstract excerpt
Functions of the Elp3 subunit of the recently purified human Elongator were studied using an in vivo yeast complementation system. We demonstrated that the human ELP3 gene (hELP3) was able partially to complement functional defects of yeast elp3Delta cells. Furthermore, a chimeric ELP3 gene (yhELP3) encoding a protein in which the putative histone acetyltransferase (HAT) domain of hELP3 fused to the remainder of...
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