Article
An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator.
The Journal of biological chemistry - 2 Jan 2009
Greenwood Catherine, Selth Luke A, Dirac-Svejstrup A Barbara, Svejstrup Jesper Q
Abstract excerpt
The Elongator complex functions in diverse cellular processes, such as RNA polymerase II transcription and tRNA modification. The Elp3 subunit possesses a C-terminal histone acetyltransferase (HAT) domain and an N-terminal sequence that resembles an iron-sulfur (FeS) cluster motif. The HAT domain is well characterized, but the role of the FeS cluster is unknown, although one report proposed that it might be...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Motifs
- Chromatin
- Histone Acetyltransferases
- Histones
- Methylation
- Multiprotein Complexes
- Mutation
- Protein Structure, Tertiary
- RNA Polymerase II