Article
Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation.
BMC genomics - 22 Jan 2010
Nugent Rebecca L, Johnsson Anna, Fleharty Brian, Gogol Madelaine, Xue-Franzén Yongtao, Seidel Chris, Wright Anthony Ph, Forsburg Susan L
Abstract excerpt
BACKGROUND: Histone acetyltransferase enzymes (HATs) are implicated in regulation of transcription. HATs from different families may overlap in target and substrate specificity. RESULTS: We isolated the elp3+ gene encoding the histone acetyltransferase subunit of the Elongator complex in fission yeast and characterized the phenotype of an Deltaelp3 mutant. We examined genetic interactions between Deltaelp3 and...
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