Article
Single nucleotide polymorphisms within the promoter region of the rhesus monkey tumor necrosis factor-alpha gene.
Immunogenetics - 1 May 2005
Singh Krishna K, Schmidtke Jörg
Abstract excerpt
The human TNF-alpha gene is characterized by several single nucleotide polymorphisms (SNPs) in its promoter region, in part having been shown to influence TNF-alpha expression and susceptibility to various diseases. The rhesus macaque is widely used as an animal model for a variety of TNF-alpha associated pathological conditions, but little is known about genetic variation within the TNF-alpha promoter region. In...
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