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Article

Identification and functional characterization of a highly polymorphic region in the human TRAIL promoter in multiple sclerosis.

Journal of neuroimmunology - 1 Apr 2004

Weber Alexandra, Wandinger Klaus-Peter, Mueller Wolf, Aktas Orhan, Wengert Oliver, Grundström Eva, Ehrlich Stefan, Windemuth Christine, Kuhlmann Tanja, Wienker Thomas, Brück Wolfgang, Zipp Frauke

Abstract excerpt

TNF-related apoptosis-inducing ligand (TRAIL) is not only involved in cell death but also in other immunoregulatory mechanisms. So far, the regulation of the TRAIL pathway in physiologic and pathologic conditions remains unclear. Due to the implication in brain damage and the elevated expression in peripheral immune cells of patients with multiple sclerosis (MS), an autoimmune disease of the central nervous...

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Share to Apoptosis Regulatory Proteins
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

Share to Multiple Sclerosis

Share to Polymorphism, Single-Stranded Conformational

Share to Statistics, Nonparametric

Share to TNF-Related Apoptosis-Inducing Ligand

Share to Transcription Factor AP-1

Source

Identifiers

PMID: 15020080
DOI: 10.1016/j.jneuroim.2003.12.014

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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