Article
CYP2C9 haplotype structure in European American warfarin patients and association with clinical outcomes.
Clinical pharmacology and therapeutics - 1 May 2005
Veenstra David L, Blough David K, Higashi Mitchell K, Farin Frederico M, Srinouanprachan Sengkeo, Rieder Mark J, Rettie Allan E
Abstract excerpt
OBJECTIVE: The goal of this study was to define the haplotype structure of the cytochrome P450 (CYP) 2C9 gene in a European American population and evaluate associations between CYP2C9 haplotypes and anticoagulation-related outcomes. METHODS: Genomic deoxyribonucleic acid from 192 European American patients stabilized on warfarin therapy was resequenced across 60 kilobases of the CYP2C9 genomic region, including...
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