Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytokine gene polymorphisms and serum cytokine levels identify a neuroinflammatory nexus in Alzheimer's disease.

Scientific reports - 13 May 2026

Wang Zhaobo, Xia Xuewei

Abstract excerpt

Neuroinflammation, orchestrated by glial cells and mediated by cytokines, is now recognized as a pivotal pathogenic mechanism in Alzheimer's disease (AD). However, the interplay between host genetic variations driving inflammatory responses and the resultant central or peripheral inflammatory milieu in AD susceptibility remains poorly defined. This study aimed to decode the crosstalk between functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alzheimer Disease
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Sectional Studies

Share to Cytokines

Share to Interleukin-10

Share to Neuroinflammatory Diseases

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 42129267
DOI: 10.1038/s41598-026-52911-y
PMCID: PMC13358141

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytokine gene polymorphisms and serum cytokine levels identify a neuroinflammatory nexus in Alzheimer's disease.PMID 42129267Read ↗

Inflammatory Cytokines and Alzheimer's Disease: A Review from the Perspective of Genetic Polymorphisms.Semantic proximity Read ↗

Associations of cytokine genes with Alzheimer's disease and depression in an elderly Korean population.Semantic proximity Read ↗

Cytokine expression profile in the human brain of older adultsSemantic proximity Read ↗

Effect of Proinflammatory Gene Polymorphisms on the Risk of Alzheimer's DiseaseSemantic proximity Read ↗

Associations between Certain Polymorphisms in Proinflammatory Cytokines and Predisposition of Alzheimer's Disease: A Meta-Analysis.Semantic proximity Read ↗

Pro-inflammatory cytokine genes influence the clinical features of frontotemporal lobar degeneration.Semantic proximity Read ↗

IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer's Disease Pathology.Semantic proximity Read ↗

Alzheimer’s Disease and Genetics of Inflammation: A Pharmacogenomic VisionSemantic proximity Read ↗

Causal effects of circulating cytokine concentrations on risk of Alzheimer’s disease: A bidirectional two-sample Mendelian randomization studySemantic proximity Read ↗

Search in the Periphery for Potential Inflammatory Biomarkers of Dementia with Lewy Bodies and Alzheimer’s DiseaseSemantic proximity Read ↗

Polymorphisms in inflammatory genes and the risk of Alzheimer disease.Semantic proximity Read ↗

Shared Genetic Etiology between Alzheimer's Disease and Blood Levels of Specific Cytokines and Growth Factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.