Article
Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration.
American journal of human genetics - 1 Jul 2005
Zareparsi Sepideh, Branham Kari E H, Li Mingyao, Shah Sapna, Klein Robert J, Ott Jurg, Hoh Josephine, Abecasis Gonçalo R, Swaroop Anand
Abstract excerpt
Using a large sample of cases and controls from a single center, we show that a T-->C substitution in exon 9 (Y402H) of the complement factor H gene is strongly associated with susceptibility to age-related macular degeneration, the most common cause of blindness in the elderly. Frequency of the C allele was 0.61 in cases, versus 0.34 in age-matched controls (P<1x10(-24)). Genotype frequencies also differ...
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