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Article

The paradox of HIV nef function: resolution of the contradictions.

Medical hypotheses - 1 Jan 2005

Sallie Richard

Abstract excerpt

The function of nef, an accessory protein of HIV, has been highly controversial. Careful studies by respected investigators have ascribed diametrically opposed functions to nef with some groups claiming nef increases replication and viral infectivity while others argue nef inhibits replication and reduces infectivity. Replicative homeostasis resolves this superficially irreconcilable paradox, and indicates both...

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Identifiers

PMID: 15893116
DOI: 10.1016/j.mehy.2005.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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