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Article

The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection.

Current HIV research - 1 Oct 2011

Vermeire Jolien, Vanbillemont Griet, Witkowski Wojciech, Verhasselt Bruno

Abstract excerpt

The Nef protein is an essential factor for lentiviral pathogenesis in humans and other simians. Despite a multitude of functions attributed to this protein, the exact role of Nef in disease progression remains unclear. One of its most intriguing functions is the ability of Nef to enhance the infectivity of viral particles. In this review we will discuss current insights in the mechanism of this well-known, yet...

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Identifiers

PMID: 22103831
DOI: 10.2174/157016211798842099
PMCID: PMC3355465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Nef-infectivity enigma: mechanisms of enhanced lentiviral infection.PMID 22103831Read ↗

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