Article
Identification of Novel Subcellular Localization and Trafficking of HIV-1 Nef Variants from Reference Strains G (F1.93.HH8793) and H (BE.93.VI997).
Viruses - 13 Sept 2018
Van Nynatten Logan R, Johnson Aaron L, Dirk Brennan S, Pawlak Emily N, Jacob Rajesh Abraham, Haeryfar S M Mansour, Dikeakos Jimmy D
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) accessory protein Nef, plays an essential role in disease progression and pathogenesis via hijacking the host cellular membrane-trafficking machinery. Interestingly, HIV-1 group-M subtypes display differences in the rate of disease progression. However, few reports investigated how the cellular behaviors and activities of Nef isolates from reference strains may...
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