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Article

Sequence analysis of reverse transcriptase genes of zidovudine (AZT)-resistant and -sensitive human immunodeficiency virus type 1 strains.

The Journal of general virology - 1 Feb 1993

Sheehy N, Desselberger U

Abstract excerpt

Sequential isolates of human immunodeficiency virus type 1 (HIV-1) were obtained from patients with AIDS on short and long term treatment with zidovudine (3'-azido-3'-deoxythymidine; AZT). The isolates were tested for resistance to zidovudine by monitoring the inhibition of syncytium formation, H...

Topics

Amino Acid Sequence
Base Sequence
Drug Resistance, Microbial
Genes, Viral
HIV Reverse Transcriptase
HIV-1
Molecular Sequence Data
Mutation
Phenotype
RNA-Directed DNA Polymerase
Zidovudine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7679140
DOI: 10.1099/0022-1317-74-2-223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7679140-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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