Article
Case-control studies of association in structured or admixed populations.
Theoretical population biology - 1 Nov 2001
Pritchard J K, Donnelly P
Abstract excerpt
Case-control tests for association are an important tool for mapping complex-trait genes. But population structure can invalidate this approach, leading to apparent associations at markers that are unlinked to disease loci. Family-based tests of association can avoid this problem, but such studies are often more expensive and in some cases--particularly for late-onset diseases--are impractical. In this review...
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