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Article

Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas.

Human pathology - 1 Apr 2005

Kawaguchi Ken-ichi, Oda Yoshinao, Saito Tsuyoshi, Takahira Tomonari, Yamamoto Hidetaka, Tamiya Sadafumi, Iwamoto Yukihide, Tsuneyoshi Masazumi

Abstract excerpt

The PTEN/MMAC1 ( PTEN ) gene was identified as a tumor suppressor gene encoding a cytoplasmic protein that controls cellular processes. To investigate the potential role and the alteration of the PTEN gene in soft tissue sarcomas (STSs), we searched for homozygous deletion and promoter hypermethylation in a series of 48 STSs that was composed of malignant fibrous histiocytoma, leiomyosarcoma, malignant peripheral...

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Source

Identifiers

PMID: 15891996
DOI: 10.1016/j.humpath.2005.01.017

Genes

PTEN
STS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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