Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy.

doi:10.1136/bmjdrc-2019-000873

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy.

BMJ open diabetes research & care - 1 Feb 2020

Gliwiński Mateusz, Iwaszkiewicz-Grześ Dorota, Wołoszyn-Durkiewicz Anna, Tarnowska Monika, Żalińska Magdalena, Hennig Matylda, Zielińska Hanna, Dukat-Mazurek Anna, Zielkowska-Dębska Joanna, Zieliński Maciej, Jaźwińska-Curyłło Anna, Owczuk Radosław, Jarosz-Chobot Przemysława, Bossowski Artur, Szadkowska Agnieszka, Młynarski Wojciech, Marek-Trzonkowska Natalia, Moszkowska Grażyna, Siebert Janusz, Myśliwiec Małgorzata, Trzonkowski Piotr

Abstract excerpt

OBJECTIVE: Here we looked for possible mechanisms regulating the progression of type 1 diabetes mellitus (T1DM). In this disease, autoaggressive T cells (T conventional cells, Tconvs) not properly controlled by T regulatory cells (Tregs) destroy pancreatic islets. RESEARCH DESIGN AND METHODS: We compared the T-cell compartment of patients with newly diagnosed T1DM (NDT1DM) with long-duration T1DM (LDT1DM) ones....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Autoantigens

Share to Autoimmunity

Share to Glutamate Decarboxylase

Share to Islets of Langerhans

Share to Proinsulin

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 32098895
DOI: 10.1136/bmjdrc-2019-000873
PMCID: PMC7206972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy.PMID 32098895Read ↗

Dysfunction of regulatory T cells in pathogenesis of type 1 diabetes mellitusSemantic proximity Read ↗

Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes.Semantic proximity Read ↗

T-Regulatory Cell Subsets in Children with Type 1 Diabetes Mellitus: Relation to Control of the Disease.Semantic proximity Read ↗

Emerging Therapeutic Strategies to Restore Regulatory T Cell Control of Islet Autoimmunity in Type 1 Diabetes.Semantic proximity Read ↗

T cells in type 1 diabetes: Instructors, regulators and effectors: A comprehensive reviewSemantic proximity Read ↗

Memory T Cells in Type 1 Diabetes: the Devil is in the Detail.Semantic proximity Read ↗

An imbalance of naïve and effector T-cell phenotypes in early type 1 diabetes across conventional and regulatory subsetsSemantic proximity Read ↗

Preproinsulin-specific regulatory T cell-derived exosomes loaded with immune checkpoint ligands can suppress autoimmune responses in type 1 diabetesSemantic proximity Read ↗

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 DiabetesSemantic proximity Read ↗

Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.Semantic proximity Read ↗

Recent advances in understanding Type 1 DiabetesSemantic proximity Read ↗

Altered regulatory T cell phenotype in latent autoimmune diabetes of the adults (LADA).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.