Article
Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly.
Cell - 25 Jul 2008
Li Qing, Zhou Hui, Wurtele Hugo, Davies Brian, Horazdovsky Bruce, Verreault Alain, Zhang Zhiguo
Abstract excerpt
Chromatin assembly factor 1 (CAF-1) and Rtt106 participate in the deposition of newly synthesized histones onto replicating DNA to form nucleosomes. This process is critical for the maintenance of genome stability and inheritance of functionally specialized chromatin structures in proliferating cells. However, the molecular functions of the acetylation of newly synthesized histones in this DNA replication-coupled...
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