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Article

Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts.

DNA repair - 8 Jun 2005

King Nicole M, Nikolaishvili-Feinberg Nana, Bryant Miriam F, Luche Douglas D, Heffernan Timothy P, Simpson Dennis A, Hanaoka Fumio, Kaufmann William K, Cordeiro-Stone Marila

Abstract excerpt

Telomerase-immortalized lines of diploid xeroderma pigmentosum variant (XP-V) fibroblasts (XP115LO and XP4BE) were complemented for constitutive or regulated expression of wild-type human DNA polymerase eta (hpol eta). The ectopic gene was expressed from a retroviral LTR at a population average of 34- to 59-fold above the endogenous (mutated) mRNA and high levels of hpol eta were detected by immunoblotting. The...

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Source

Identifiers

PMID: 15886068
DOI: 10.1016/j.dnarep.2005.04.002

Genes

POLH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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