Article
High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing.
PLoS genetics - 1 May 2006
Tiemann-Boege Irene, Calabrese Peter, Cochran David M, Sokol Rebecca, Arnheim Norman
Abstract excerpt
For decades, classical crossover studies and linkage disequilibrium (LD) analysis of genomic regions suggested that human meiotic crossovers may not be randomly distributed along chromosomes but are focused instead in "hot spots." Recent sperm typing studies provided data at very high resolution and accuracy that defined the physical limits of a number of hot spots. The data were also used to test whether...
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