Article
Human recombination hot spots hidden in regions of strong marker association.
Nature genetics - 1 Jun 2005
Jeffreys Alec J, Neumann Rita, Panayi Maria, Myers Simon, Donnelly Peter
Abstract excerpt
The fine-scale distribution of meiotic recombination events in the human genome can be inferred from patterns of haplotype diversity in human populations but directly studied only by high-resolution sperm typing. Both approaches indicate that crossovers are heavily clustered into narrow recombination hot spots. But our direct understanding of hot-spot properties and distributions is largely limited to sperm...
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