High-resolution mapping of crossovers in human sperm defines a minisatellite-associated recombination hotspot.

doi:10.1016/s1097-2765(00)80138-0

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Article

High-resolution mapping of crossovers in human sperm defines a minisatellite-associated recombination hotspot.

Molecular cell - 1 Aug 1998

Jeffreys A J, Murray J, Neumann R

Abstract excerpt

Little is known about the fine-scale distribution of meiotic crossovers in human chromosomes. Methods have therefore been developed for detecting and mapping recombination products directly in human sperm DNA. Analysis of crossovers adjacent to the GC-rich minisatellite MS32, which is known to mu...

Topics

Alleles
Base Sequence
Chromosome Breakage
Chromosome Mapping
Crossing Over, Genetic
DNA Primers
DNA, Recombinant
Haplotypes
Humans
Linkage Disequilibrium
Male
Meiosis
Minisatellite Repeats
Polymerase Chain Reaction
Recombination, Genetic
Spermatozoa

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