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Article

Meiotic recombination hot spots and human DNA diversity.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2004

Jeffreys Alec J, Holloway J Kim, Kauppi Liisa, May Celia A, Neumann Rita, Slingsby M Timothy, Webb Adam J

Abstract excerpt

Meiotic recombination plays a key role in the maintenance of sequence diversity in the human genome. However, little is known about the fine-scale distribution and processes of recombination in human chromosomes, or how these impact on patterns of human diversity. We have therefore developed sperm typing systems that allow human recombination to be analysed at very high resolution. The emerging picture is that...

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Identifiers

PMID: 15065666
DOI: 10.1098/rstb.2003.1372
PMCID: PMC1693298

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