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Article

Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter.

Molecular and cellular endocrinology - 15 Jul 2005

Brockman Jennifer L, Schuler Linda A

Abstract excerpt

Prolactin (PRL) modulates proliferation in the mammary gland and other tissues, in part through inducing transcription of cyclin D1, a key regulator of G(1) phase cell cycle progression. We showed previously that PRL, via Jak2, induces binding of Stat5 to a distal GAS site (GAS1) in the cyclin D1 promoter. However, full promoter activity requires additional regions, and in this paper we explored PRL-induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15885880
DOI: 10.1016/j.mce.2005.04.006
PMCID: PMC1635012

Genes

PRL
GAS1
GAS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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