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Article

PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.

The EMBO journal - 3 Mar 2010

Chan Chi-Bun, Liu Xia, Ensslin Michael A, Dillehay Dirck L, Ormandy Christopher J, Sohn Philip, Serra Rosa, Ye Keqiang

Abstract excerpt

PI 3-kinase enhancer A (PIKE-A) is critical for the activation of Akt signalling, and has an essential function in promoting cancer cell survival. However, its physiological functions are poorly understood. Here, we show that PIKE-A directly associates with both signal transducer and activator of transcription 5a (STAT5a) and prolactin (PRL) receptor, which is essential for PRL-provoked STAT5a activation and the...

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Source

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Identifiers

PMID: 20075866
DOI: 10.1038/emboj.2009.406
PMCID: PMC2837170

Genes

PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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