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Article

Truncating Prolactin Receptor Mutations Promote Tumor Growth in Murine Estrogen Receptor-Alpha Mammary Carcinomas.

Cell reports - 27 Sept 2016

Griffith Obi L, Chan Szeman Ruby, Griffith Malachi, Krysiak Kilannin, Skidmore Zachary L, Hundal Jasreet, Allen Julie A, Arthur Cora D, Runci Daniele, Bugatti Mattia, Miceli Alexander P, Schmidt Heather, Trani Lee, Kanchi Krishna-Latha, Miller Christopher A, Larson David E, Fulton Robert S, Vermi William, Wilson Richard K, Schreiber Robert D, Mardis Elaine R

Abstract excerpt

Estrogen receptor alpha-positive (ERα+) luminal tumors are the most frequent subtype of breast cancer. Stat1(-/-) mice develop mammary tumors that closely recapitulate the biological characteristics of this cancer subtype. To identify transforming events that contribute to tumorigenesis, we performed whole genome sequencing of Stat1(-/-) primary mammary tumors and matched normal tissues. This investigation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Mammary Neoplasms, Animal

Share to Receptors, Prolactin

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Source

Open in PubMed Open full text

Identifiers

PMID: 27681435
DOI: 10.1016/j.celrep.2016.08.076
PMCID: PMC5557050

Genes

PRLR
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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