Article
The prolactin receptor transactivation domain is associated with steroid hormone receptor expression and malignant progression of breast cancer.
The American journal of pathology - 1 Jan 2013
Fiorillo Alyson A, Medler Terry R, Feeney Yvonne B, Wetz Suzanne M, Tommerdahl Kalie L, Clevenger Charles V
Abstract excerpt
The polypeptide hormone prolactin (PRL) stimulates breast epithelial cell growth, differentiation, and motility through its cognate receptor, PRLr. PRLr is expressed in most breast cancers; however, its exact role remains elusive. Our laboratory previously described a novel mode of PRLr signaling in which Stat5a-mediated transcription is regulated through ligand-induced phosphorylation of the PRLr transactivation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.