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Article

A model for target protein binding to calcium-activated S100 dimers.

FEBS letters - 16 Jan 1998

Groves P, Finn B E, Kuźnicki J, Forsén S

Abstract excerpt

S100 proteins are a family of dimeric calcium-binding proteins implicated in several cancers and neurological diseases. Calbindin D9k is an unusual monomeric member of the S100 family. A calbindin D9k mutant containing a novel calcium-induced helix is characterized. Based on sequence comparison, this helix could be a component of other S100 proteins and a factor in target protein binding. The origin of structural...

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PMID: 9468301
DOI: 10.1016/s0014-5793(97)01535-4

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