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Article

Dermal mast cells play a central role in the incidence of scratching behavior in mice induced by multiple application of the hapten, 2,4,6-trinitrochlorobenzene.

Experimental dermatology - 1 Jun 2005

Yamashita Hirotaka, Michibata Yoshiko, Mizukami Hajime, Ogihara Yukio, Morita Akimichi, Nose Mitsuhiko

Abstract excerpt

Repeated application of 1% 2,4,6-trinitrochlorobenzene (TNCB) in acetone solution causes chronic skin inflammation in BALB/c mice. Associated scratching behavior gradually appeared, and chronic scratching behavior was established over 40 days after the initial application of TNCB. In order to explore the possible involvement of T cells and mast cells in the appearance of pruritus, we examined the response of...

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Identifiers

PMID: 15885079
DOI: 10.1111/j.0906-6705.2005.00304.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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