Article
CFTR-deficiency renders mice highly susceptible to cutaneous symptoms during mite infestation.
Laboratory investigation; a journal of technical methods and pathology - 1 Apr 2011
Hashimoto Yasuaki, Shuto Tsuyoshi, Mizunoe Shota, Tomita Azusa, Koga Tomoaki, Sato Takashi, Takeya Motohiro, Suico Mary Ann, Niibori Akiko, Sugahara Takuya, Shimasaki Shogo, Sugiyama Takashi, Scholte Bob, Kai Hirofumi
Abstract excerpt
Pruritus, also known as itch, is a sensation that causes a desire to scratch. Prolonged scratching exacerbates skin lesions in several skin diseases such as atopic dermatitis. Here, we identify the cystic fibrosis transmembrane conductance regulator (CFTR/Cftr), an integral membrane protein that mediates transepithelial chloride transport, as a determinant factor in mice for the susceptibility to several...
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