Article
Genetic and Imaging Approaches Reveal Pro-Inflammatory and Immunoregulatory Roles of Mast Cells in Contact Hypersensitivity.
Frontiers in immunology - 1 Jan 2018
Gaudenzio Nicolas, Marichal Thomas, Galli Stephen J, Reber Laurent L
Abstract excerpt
Contact hypersensitivity (CHS) is a common T cell-mediated skin disease induced by epicutaneous sensitization to haptens. Mast cells (MCs) are widely deployed in the skin and can be activated during CHS responses to secrete diverse products, including some with pro-inflammatory and anti-inflammatory functions. Conflicting results have been obtained regarding pathogenic versus protective roles of MCs in CHS, and...
Topics
- Animals
- Biomarkers
- Cell Degranulation
- Cytokines
- Dermatitis, Contact
- Disease Models, Animal
- Genetic Predisposition to Disease
- Humans
- Inflammation Mediators
- Mast Cells
- Microscopy, Fluorescence
- Molecular Imaging
- Secretory Vesicles