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Article

In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

10 Nov 2008

Abstract excerpt

High dose bee venom exposure in beekeepers by natural bee stings represents a model to understand mechanisms of T cell tolerance to allergens in healthy individuals. Continuous exposure of nonallergic beekeepers to high doses of bee venom antigens induces diminished T cell-related cutaneous late-phase swelling to bee stings in parallel with suppressed allergen-specific T cell proliferation and T helper type 1...

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PMID: 19001136
DOI: 10.1084/jem.20080193

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