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Article

Modification of blood cell PrP epitope exposure during prion disease.

The Biochemical journal - 1 Sept 2005

Thackray Alana M, Ryder Stephen J, Bujdoso Raymond

Abstract excerpt

PrPC [normal cellular PrP (prion-related protein)] is a glycosylphosphatidylinositol-linked cell-surface glycoprotein that is expressed primarily by cells of the central and peripheral nervous system and the lymphoreticular system. During prion disease, PrPC undergoes structural modification to PrPSc (abnormal disease-specific conformation of PrP). The appearance of prion infectivity and PrPSc within different...

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Identifiers

PMID: 15885031
DOI: 10.1042/BJ20050571
PMCID: PMC1198936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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