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Article

Antigenic characterization of an abnormal isoform of prion protein using a new diverse panel of monoclonal antibodies.

Virology - 1 Mar 2004

Kim Chan-Lan, Umetani Atsushi, Matsui Toshio, Ishiguro Naotaka, Shinagawa Morikazu, Horiuchi Motohiro

Abstract excerpt

We established a panel of monoclonal antibodies (mAbs) against prion protein (PrP) by immunizing PrP gene-ablated mice with the pathogenic isoform of prion protein (PrPSc) or recombinant prion protein (rPrP). The mAbs could be divided into at least 10 groups by fine epitope analyses using mutant rPrPs and pepspot analysis. Seven linear epitopes, lying within residues 56-90, 119-127, 137-143, 143-149, 147-151,...

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Identifiers

PMID: 15003861
DOI: 10.1016/j.virol.2003.10.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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