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Article

ENU mutation mapped to a distal region of chromosome 11 is a major determinant of bone size.

Physiological genomics - 15 Dec 2013

Edderkaoui Bouchra, Kesavan Chandrasekhar, Baylink David J, Wergedal Jon E, Srivastava Apurva K, Mohan Subburaman

Abstract excerpt

Using a phenotype driven n-ethyl-nitrosourea (ENU) screen in growth hormone-deficient mice, we have identified a mutant (named 14104) that exhibited a smaller bone size. Phenotype measurements by microcomputed tomography revealed that mutant mice exhibited a 43 and 34% reduction in tissue area and bone area, respectively at the femur middiaphysis. Dynamic histomorphometry revealed a 30 and 15% lower bone...

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Identifiers

PMID: 24151243
DOI: 10.1152/physiolgenomics.00142.2013
PMCID: PMC3882684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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