Chemical mutagenesis induced two high bone density mouse mutants map to a concordant distal chromosome 4 locus.

Abstract excerpt

Phenotype-driven mutagenesis approach in the mouse holds much promise as a method for revealing gene function. Earlier, we have described an N-ethyl-N-nitrosourea (ENU) mutagenesis screen to create genome-wide dominant mutations in the mouse model. Using this approach, we describe identification of two high bone density mutants in C57BL/6J (B6) background. The mutants, named as 12184 and 12137, have been bred...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Density
• Share to Cell Proliferation
• Share to Gene Expression Profiling