Article
A novel ENU-induced mutation, peewee, causes dwarfism in the mouse.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jul 2009
Lee Bokryeon, Bokryeon Lee, Kano Kiyoshi, Young Jay, John Simon W M, Nishina Patsy M, Naggert Jurgen K, Naito Kunihiko
Abstract excerpt
We identified a novel fertile autosomal recessive mutation called peewee that results in dwarfing, in a region-specific ENU-induced mutagenesis. These mice at litter size were smaller those of other strains. Histological analysis revealed that the major organs appear normal, but abnormalities in cellular proliferation were observed in bone, liver, and testis. Haplotype analysis localized the peewee gene to a...
Topics
- Animals
- Apoptosis
- Cell Proliferation
- Chromosome Mapping
- Dwarfism
- Ethylnitrosourea
- Female
- Gene Expression
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutagenesis
- Mutagens
- Mutation