Article
Dosage-dependent requirement for mouse Vezf1 in vascular system development.
Developmental biology - 1 Jul 2005
Kuhnert Frank, Campagnolo Luisa, Xiong Jing-Wei, Lemons Derek, Fitch Michael J, Zou Zhongmin, Kiosses William B, Gardner Humphrey, Stuhlmann Heidi
Abstract excerpt
Vezf1 is an early development gene that encodes a zinc finger transcription factor. In the developing embryo, Vezf1 is expressed in the yolk sac mesoderm and the endothelium of the developing vasculature and, in addition, in mesodermal and neuronal tissues. Targeted inactivation of Vezf1 in mice reveals that it acts in a closely regulated, dose-dependent fashion on the development of the blood vascular and...
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