Article
Analysis of the Pax-3 gene in the mouse mutant splotch.
Genomics - 1 Aug 1993
Goulding M, Sterrer S, Fleming J, Balling R, Nadeau J, Moore K J, Brown S D, Steel K P, Gruss P
Abstract excerpt
In a linkage analysis of Pax-3 and splotch no recombinations were found in 117 backcross mice. Molecular analysis of Pax-3 in three alleles of splotch shows a number of significant alterations to the Pax-3 gene. In Sp/Sp embryos, cDNA PCR analysis reveals a shortened transcript in which exon 4 of...
Topics
- Alleles
- Alternative Splicing
- Animals
- Base Sequence
- Chromosome Mapping
- Crosses, Genetic
- Female
- Gene Deletion
- Genetic Linkage
- Heterozygote
- Homozygote
- Male
- Mice
- Mice, Inbred C3H
- Mice, Neurologic Mutants
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides