Article
A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors.
Developmental biology - 1 Nov 1998
Tremblay P, Dietrich S, Mericskay M, Schubert F R, Li Z, Paulin D
Abstract excerpt
Activated by dorsalizing and lateralizing signals, the Pax3 gene is an early marker for the entire paraxial mesoderm and its dorsal derivative, the dermomyotome. Later, its expression becomes restricted to the lateral dermomyotome and to the migratory muscle precursors giving rise to the hypaxial...
Topics
- Animals
- Bone Development
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Gene Expression Regulation, Developmental
- Histocytochemistry
- Lac Operon
- Mesoderm
- Mice
- Mice, Transgenic
- Muscle Development
- Muscle, Skeletal
- Mutation
- PAX3 Transcription Factor
- Paired Box Transcription Factors
- Transcription Factors
- Transgenes