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Article

Analysis of neural crest cell migration in Splotch mice using a neural crest-specific LacZ reporter.

Developmental biology - 15 May 1997

Serbedzija G N, McMahon A P

Abstract excerpt

Studies on the mouse Splotch (Sp) mutation, a deletion in the transcription factor Pax-3, have revealed that Pax-3 is essential for normal development of the neural crest. We have investigated the defect in neural crest development using a Wnt-l::LacZ reporter construct to mark neural crest cells. Staining embryos for beta-galactosidase activity at different developmental stages revealed a severe reduction in the...

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PMID: 9187079
DOI: 10.1006/dbio.1997.8551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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