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Article

Alginate acetylation influences initial surface colonization by mucoid Pseudomonas aeruginosa.

Microbiological research - 1 Jan 2005

Tielen Petra, Strathmann Martin, Jaeger Karl-Erich, Flemming Hans-Curt, Wingender Jost

Abstract excerpt

Mucoid strains of Pseudomonas aeruginosa overproduce the exopolysaccharide alginate, which is substituted with O-acetyl groups. Under non-growing conditions in phosphate buffer, a mucoid clinical strain formed microcolonies on steel surfaces, while an acetylation-defective mutant was unable to form cell clusters. Enzymatic degradation of alginate by alginate lyase prevented microcolony formation of the mucoid...

Topics

Acetylation
Alginates
Bacterial Adhesion
Biofilms
Culture Media
Glucuronic Acid
Hexuronic Acids
Humans
Mutation
Polysaccharide-Lyases
Polysaccharides, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pseudomonas aeruginosa

Source

Identifiers

PMID: 15881834
DOI: 10.1016/j.micres.2004.11.003

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Alginate acetylation influences initial surface colonization by mucoid Pseudomonas aeruginosa.PMID 15881834Read ↗

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