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Article

ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa.

Microbiology (Reading, England) - 1 Jul 2008

Qiu Dongru, Eisinger Vonya M, Head Nathan E, Pier Gerald B, Yu Hongwei D

Abstract excerpt

Overproduction of the exopolysaccharide alginate and conversion to a mucoid phenotype in Pseudomonas aeruginosa are markers for the onset of chronic lung infection in cystic fibrosis (CF). Alginate production is regulated by the extracytoplasmic function (ECF) sigma factor AlgU/T and the cognate anti-sigma factor MucA. Many clinical mucoid isolates carry loss-of-function mutations in mucA. These mutations,...

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Identifiers

PMID: 18599839
DOI: 10.1099/mic.0.2008/017368-0
PMCID: PMC2995304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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