Article
Studying the effect of alginate overproduction on Pseudomonas aeruginosa biofilm by atomic force microscopy.
Journal of nanoscience and nanotechnology - 1 Jul 2011
Lim Jeesun, Cui Yidan, Oh Yoo Jin, Park Ja Ryeong, Jo William, Cho You-Hee, Park Sungsu
Abstract excerpt
Pseudomonas aeruginosa is the most important pathogen in cystic fibrosis patients and forms biofilms in the lung. P. aeruginosa strains isolated from the lungs of the patients have a mucoid phenotype overproducing alginate. The phenotype forms highly structured biofilms which are more resistant to antibiotics than biofilms formed by its nonmucoid phenotype. Conversion to the alginate-overproducing phenotype...
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