Article
Cytotoxic T-lymphocyte antigen 4 gene polymorphisms in sarcoidosis patients.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG - 1 Mar 2005
Hattori Noriko, Niimi Takashi, Sato Shigeki, Achiwa Hiroyuki, Maeda Hiroyoshi, Oguri Tetsuya, Bessho Yuji, Ito Hidemi, Shimizu Shigeki, Ueda Ryuzo
Abstract excerpt
BACKGROUND AND AIM: Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a co-stimulatory molecule that is expressed on activated T-cells, and is an important regulator of T-cell activation in T-cell-dependent immune responses. CTLA-4 signals lead to the downregulation of T-cell proliferation and activation. Sarcoidosis is a systemic granulomatous disorder of unknown etiology, which shows abnormal regulation of T cell...
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