Article
Variation in IL7R predisposes to sarcoid inflammation.
Genes and immunity - 1 Oct 2009
Heron M, Grutters J C, van Moorsel C H M, Ruven H J T, Huizinga T W J, van der Helm-van Mil A H M, Claessen A M E, van den Bosch J M M
Abstract excerpt
Sarcoidosis is a chronic granulomatous disorder characterized by a massive influx of Th1 lymphocytes. Both naive and memory T cells express high levels of interleukin 7 receptor-alpha (IL7R alpha), encoded by the IL7R gene. The purpose of this study was to investigate the role of the IL7R gene region in susceptibility to sarcoidosis. Six common single-nucleotide polymorphisms (SNPs) spanning IL7R were genotyped...
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