Article
Cytotoxic T-lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism affects lymphocyte profiles in bronchoalveolar lavage of patients with sarcoidosis.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG - 1 Oct 2003
Handa Tomohiro, Nagai Sonoko, Ito Isao, Shigematsu Michio, Hamada Kunio, Kitaichi Masanori, Izumi Takateru, Mishima Michiaki
Abstract excerpt
BACKGROUND: Sarcoidosis is a systemic disease characterized by T-cell activation and subsequent granuloma formation at the site of involvement. Genetic susceptibility is a key factor in the pathogenesis of this disease, and genes involved in T-cell regulation are potential candidates. Cytotoxic T...
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