Article
Association analysis of single nucleotide polymorphisms in cartilage-specific collagen genes with knee and hip osteoarthritis in the Japanese population.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2002
Ikeda Toshiyuki, Mabuchi Akihiko, Fukuda Akira, Kawakami Akira, Ryo Yamada, Yamamoto Seizo, Miyoshi Kota, Haga Nobuhiko, Hiraoka Hisatada, Takatori Yoshio, Kawaguchi Hiroshi, Nakamura Kozo, Ikegawa Shiro
Abstract excerpt
Osteoarthritis (OA) is one of the most common diseases in the elderly. Although its pathophysiology is complex and its molecular basis remains to be determined, much evidence suggests that OA has strong genetic determinants. To search for susceptibility loci of OA, we selected seven candidate genes encoding cartilage-specific collagens (type II, IX, X, and XI collagens) and performed association analysis for OA...
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