Article
Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis.
Annals of human genetics - 1 Sept 1999
Meulenbelt I, Bijkerk C, De Wildt S C, Miedema H S, Breedveld F C, Pols H A, Hofman A, Van Duijn C M, Slagboom P E
Abstract excerpt
It was investigated whether radiographic osteoarthritis (ROA) is associated with specific haplotypes of the COL2A1 gene. Radiographs of knees, hips, hands, and spine were scored for the presence of ROA in subjects of 55-70 years from a population-based cohort study, the Rotterdam study. Cases had ROA in 3 or more joint groups; controls, from the same population, had ROA in less than 3 joint groups. Allele...
Topics
- Aged
- Alleles
- Collagen
- Female
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Osteoarthritis
- Phenotype
- Polymorphism, Restriction Fragment Length
- Radiography